STRP

Clemson University

StressDetect: Real-Time Monitoring CHO Cell Stress to Enhance Biopharmaceutical Production

Lead: Jessica Larsen

Amount: $100000

Intellectual Property Status: Invention disclosure

Award Date: 04/01/2025

End Date: 03/31/2025

ABSTRACT

The primary objective of this project is to validate StressDetect as an innovative real time stress-monitoring tool for CHO cell-based biomanufacturing through the following stages: 1. Develop/Standardize ROS Modulation in CHO Cultures to Simulate Industry Conditions, 2. Validate StressDetect as Industry-Ready Stress Monitoring Tools, 3. Optimize and Pilot-Test StressDetect for Biomanufacturing Commercialization. Finally, collaborate with industry partners for pilot-scale validation, laying the groundwork for product development, licensing opportunities, and commercialization in CHO cell-based biomanufacturing processes.

This is not the NSF website for the ART program. The development of this portal is supported by the U.S. National Science Foundation under Award No. 2331429. The material on this portal is sourced from the various activities and projects being supported the ART program. Any opinions, findings and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the U.S. National Science Foundation.

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