This project aims to develop and validate RoutePEARL (Route Planner for Efficient Aerial and Road Logistics) – a cloud-based route optimization platform for trucks (including EV trucks) and UAVs or drones. RoutePEARL uniquely integrates operational and network communication decisions, ensuring seamless coordination between vehicles while prioritizing safety, efficiency, and sustainability. The platform enables efficient route planning and real-time route adjustments for three types of last-mile distribution modes: (1) UAV-based point-to-point delivery, (2) electric truck-based distribution, and (3) hybrid truck-drone delivery, where trucks and UAVs work in tandem to deliver packages. The platform leverages advanced algorithms and real-time data to reduce delivery costs by 20%, improve fleet utilization by 25%, and lower carbon emissions by 15%.