STRP

University of Massachusetts Amherst

HasenTech; Developing a Safe Therapeutic to Dampen Pathological Inflammation in Graft Versus Host Disease

Lead: Barbara Osborne

Amount: $100000

Intellectual Property Status: Patent

Award Date: 09/01/2024

End Date: 09/01/2025

ABSTRACT

HasenTech Inc. is an early-stage biotech start-up developing a novel anti-inflammatory exopolysaccharide (EPS) from Bacillus subtilis to treat inflammatory diseases, with an initial focus on graft versus host disease (GvHD). HasenTech is collaborating with clinical expert and regulatory consultants to design first-in-human (FIH) trials. Specific objectives of the NSF ART project include developing an activity assay for EPS, scaling up manufacturing, optimizing purification, and preparing for FIH studies with the FDA.