Lead: Blake Wiedenheft
Keywords: RNA editing, CRISPR, genetic engineering, RNA cleavage
Amount: $208700
Intellectual Property Status: Patent
Award Date: 02/01/2024
End Date: 01/30/2026
ABSTRACT
CRISPR RNA-guided endonucleases have enabled precise editing of DNA. However, options for editing RNA remain limited. Here, we combine sequence-specific RNA cleavage by CRISPR RNA-guided ribonucleases with programmable RNA repair to make precise deletions and insertions in RNA. This work establishes a new recombinant RNA technology with immediate applications for the facile engineering of RNA viruses.
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